What researchers have discovered about sugary sodas changes everything we thought we knew about the microbiota

Thursday 13 November 2025 15:30 - Adèle Peyches
What researchers have discovered about sugary sodas changes everything we thought we knew about the microbiota

Did you think that the sugar in soft drinks "only" gave you cavities or a few extra pounds?

According to a study relayed by Slate, the reality is a little more surprising: refined sugar can modify the genetic behavior of your intestinal bacteria. Yes, you read that right...


Cool bacteria that switch sides

Researchers have studied a well-known intestinal bacterium: Bacteroides thetaiotaomicron.

Normally, it's one of the "good guys" in our microbiota. It helps digestion, supports the immune system and contributes to intestinal balance. But under the influence of refined white sugar, it starts to act... differently.

According to the article published by New Atlas and picked up by Slate, this sugar causes an inversion of the bacterium's DNA - a bit like turning parts of its genetic code inside out. This transformation does not destroy the bacterium, but changes the genes it activates. As a result, it temporarily "disguises" itself and ceases to play its beneficial role.

A temporary transfer... but not insignificant

Researchers compare this inversion to a genetic "costume change".

Nothing irreversible: when the effects of sugar disappear, the bacteria revert to their original form.

But repeated exposure - typically, regular consumption of sweetened beverages - could accentuate this mechanism and unbalance the microbiota.

What's more surprising? Until now, this phenomenon has been observed in pathogenic bacteria such as E. coli or Salmonella, which use this ability to evade the immune system.

To see the same reaction in a normally beneficial bacterium is what scientists call "surprising and worrying".

Simply put: refined sugar can turn an allied bacterium into an intestinal double agent.

Sugar, a trigger for inflammation

The researchers also observed that after exposure to these sugars, the "modified" bacteria were accompanied by an abnormal immune response.

Inflammatory markers such as cytokines increased, indicating that the body was reacting as if to a threat.

Even if the bacteria eventually return to their normal state, frequent consumption of sodas or sweetened products could sustain low-grade inflammation, the kind found in many digestive or metabolic disorders.

In concrete terms, what does this mean for us?

No need to ban sugar for life (phew!), but this study shows just how sensitive our microbiota is to what we eat.

Every sweet drink we swallow not only feeds our taste buds: it also affects the biological balance of our intestinal flora.

And the more this flora is disturbed, the more it influences our health - digestion, immune system, mood, everything.

In other words :

  • Yes, an occasional soda is fine.
  • But consuming it often is like pressing the "imbalance" button on your intestine over and over again.

The last word

Sugar is not the enemy, but it is a food that profoundly changes our bodies, right down to the microscopic level.

As Slate summarizes, these findings are a reminder that "refined sugar turns part of your gut microbiota against you".

So, before you open a new can, remember: your gut didn't ask to go into "genetic mutation" mode.

Adèle PeychesAdèle Peyches
Editorial manager who just can't wait for winter to enjoy fondue! Passionate about gastronomy and always on the lookout for new culinary gems, I first studied law before returning to my first love: the taste of good products and the joy of sharing around the table :)

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